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Articolo n° 575362 del 23 Aprile 2022 delle ore 08:59

New overlying epithelium are hyperplastic parakeratotic stratified squamous epithelium proving several elongated rete ridges

New overlying epithelium are hyperplastic parakeratotic stratified squamous epithelium proving several elongated rete ridges


In jaws periodontium can display different types of focal overgrowths. These lesions occur due to overgrowth and growth various parts out-of conjunctive structure into the periodontium, i.e. new material, limbs, cementum, blood-vessel otherwise one style of sort of mobile. The fresh new lexicon regarding focal proliferative lesions commonly taking place toward gingival structure includes fibroma, large cellphone fibroma, pyogenic granuloma, peripheral monster phone granuloma, POF and you may POdF. Most of these lesions is reactive persistent inflammatory hyperplasias, which have minor trauma otherwise persistent irritation being the etiologic circumstances.

The latest nomenclature of those sores is done in a sense to stress the real difference in nature of growth, area from development, source and also the dominating proliferating histological part/structure about lesion. The brand new sores being present intraosseously are known as “central sores”, whereas their extraosseous equivalents and/or lesions and therefore appear on outer softer muscle (e.grams. gingiva) was called “peripheral sores”. In addition to, a good lesion mation due to a stimulus which is called as a beneficial “activated lesion” otherwise it may be it is “neoplastic” in which it’s categorized given that a safe or a cancerous neoplasm.

The newest POF, representing an activated benign lesion of connective muscle, is not the mellow tissues equal (otherwise related anyway) to help you central ossifying fibroma and this is short for a keen osteogenic neoplasm

The phrase POF is created from the Eversole and Robin. It happens solely with the gingiva. It is a relatively popular development of gingiva that is noticed to be activated in nature unlike neoplastic. POF are described as a high degree of cellularity constantly appearing bone creation, in the event occasionally, cementum-such as thing or dystrophic calcification may also be discover.

While the lesion occurs simply to your gingiva that will be supposed to getting based on periodontal ligaments, particular regulators felt new lesion to get odontogenic in source.

Currently, the origin and you will pathogenesis of your own lesion was not familiar. However, with their scientific and you may histopathologic resemblance, it is believed that about some instances regarding POF can get develop right down to growth out of an extended-position pyogenic granuloma.

The newest POF possess an optimum incidence in the younger and teenaged lady. Cundiff stated that the fresh lesion are prevalent between ages of 5 and you will twenty five years, with a top chance from the thirteen yrs . old. Cundiff also stated one female predilection. Female so you’re able to men ratio may differ out of 2:step 1 to 3:dos. This site regarding occurrence out of POF is frequently prior to help you molars both in maxilla and you may mandible just as, and in more 50% away from circumstances regarding the incisor, and you will cuspid nations.

Clinically, the fresh new lesion looks like a nodular bulk which may be pedunculated or sessile, green in order to red for the color and you will body might be although not usually ulcerated. In the modern circumstances plus, the brand new lesion took place a middle-aged people for the mandibular prior region and you can appeared since a great nodular soft to help you red progress instead of ulceration.

Histopathologically, the fresh lesion suggests stratified squamous epithelium level an extremely mobile mass away from connective tissue composed of fat fibroblasts, fibrocytes, fibrillar stroma and regions of mineralization with multinucleated giant tissues near him or her in many cases. The newest mineralization could possibly get feature bones, cementum-like topic otherwise dystrophic calcifications. The new dystrophic calcifications are present in very early, ulcerated lesions, while the fresh new older, mature, non-ulcerated lesions let you know really-designed bone and cementum-for example point, once the is apparent in the modern circumstances together with.

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This new logical differential analysis regarding POF boasts most of the nodular lesions and that exist into gingiva (as mentioned before). Histopathologically, it’s important to understand the difference between the same sounding sores, i.elizabeth. POF, POdF, central ossifying fibroma (COF) and you will central odontogenic fibroma (COdF).

» F. Lammardo

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